Высылаю повторно, т.к. мне этот мой ответ так и не вернулся
> Esop, салют!
> E> В результате масштабного исследования ученые из США
> Имена, ссылки на НАУНЫЕ статьи в НАУЧНЫХ журналах, статистка, валидность,
> ссылочный аппарат.
> Что значит "ПО ИХ ДАННЫМ" .
> Это для газеты формулировка.
> СКОЬКО лет проводлось иследование? На какой группе?
> Какова группа контрольная?
> Но в любом случае это не научная статья, а популярный трёп.
>
Привет Леонид!
Association of bodyweight with total mortality and with cardiovascular
events in coronary artery disease: a systematic review of cohort studies,
The Lancet, Volume 368, Number 9536, 19 August 2006
http://download.thelancet.com/pdfs/journals/0140-6736/PIIS0140673606692519.pdf
Summary
Background
Studies of the association between obesity, and total mortality and
cardiovascular events in patients with coronary artery disease (CAD) have
shown contradictory results. We undertook a systematic review to determine
the extent and nature of this association.
Methods
We selected cohort studies that provided risk estimates for total mortality,
with or without cardiovascular events, on the basis of bodyweight or obesity
measures in patients with CAD, and with at least 6 months' follow-up. CAD
was defined as history of percutaneous coronary intervention, coronary
artery bypass graft, or myocardial infarction. We obtained risk estimates
for five predetermined bodyweight groups: low, normal weight (reference),
overweight, obese, and severely obese.
Findings
We found 40 studies with 250,152 patients that had a mean follow-up of 38
years. Patients with a low body-mass index (BMI) (ie, <20) had an increased
relative risk (RR) for total mortality (RR=137 [95% CI 132-143), and
cardiovascular mortality (145 [116-181]), overweight (BMI 25-29.9) had
the lowest risk for total mortality (087 [081-094]) and cardiovascular
mortality (088 [075-102]) compared with those for people with a normal
BMI. Obese patients (BMI 30-35) had no increased risk for total mortality
(093 [085-103]) or cardiovascular mortality (097 [082-115]). Patients
with severe obesity (35) did not have increased total mortality (110
[087-141]) but they had the highest risk for cardiovascular mortality
(188 [105-334]).
Interpretation
The better outcomes for cardiovascular and total mortality seen in the
overweight and mildly obese groups could not be explained by adjustment for
confounding factors. These findings could be explained by the lack of
discriminatory power of BMI to differentiate between body fat and lean mass.
Affiliations
a. Division of Cardiovascular Diseases, Mayo Clinic College of Medicine,
Mayo Foundation, Rochester, MN 55905, USA
b. Department of Internal Medicine, Knowledge and Encounter Research, Mayo
Clinic College of Medicine, Mayo Foundation, Rochester, MN 55905, USA
Correspondence to: Francisco Lopez-Jimenez
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