вот и прояснилось всё с перекисью :)
на животных лишь в одном эксперименте показана способность продлевать жизнь,
- и то не намного, - 9%.
в других случаях сокращение сроков жизни!
это инфа для тех, кто уже хотел перекись кушать.
как я и говорил, тут всё зависит от дозы - маленькая ошибка и эффект отрицательный!
думаю нам стоит забыть если не навсегда, то надолго о перикиси, - может когда-то
появятся чёткие проверенные рекомендации о дозах для людей.
пока же гораздо разумнее использовать ионизаторы, эффект они дают тот же (гормезис-адаптация
к свободным радикалам), зато проверены как следует и выраженно ни раз продлевали
жизнь в экспериментах. биолог Виленчик приводит цифру в 50% на мышах, как максимум.
С уважением, Рязанов Дмитрий.
Продление жизни, научный иммортализм
www.bessmertie.ru Dmit***@b*****.ru
| | IA> хЯРНВМХЙ: CryoNet Message #25555
IA> Date: Sat, 15 Jan 2005 12:24:10 -0800 (PST) |
| | IA> From: Doug Skrecky <ober***@v*****.ca>
IA> Subject: trace episodic hydrogen peroxide as a life extender? |
| | IA> [Episodic 20 mM H2O2 increased human skin
IA> cell longevity in vitro by
IA> 60%.
IA> (ref #1) This intriguing result has not (yet)
IA> been followed up on with an
IA> in vivo rodent longevity experiment. There was one study on house flies
IA> which found that a steady state concentration of 10 mM H2O2 in drinking
IA> water increased average lifespan by 9%. (ref #2) However 5 mM H2O2
IA> reduced lifespan by 16%, and 100 mM H2O2 reduced it by 27%. Although 10
IA> mM increased fly's glutathione by 98%, 5 mM
IA> actually decreased this by 8%.
IA> Perhaps it is just as well that a potential antiaging medication
IA> commonly found in the house has been ignored. High doses of hydrogen
IA> peroxide accelerate cellular senescence, and anyone taking very low
IA> "hormetic" doses of it to prevent aging would be playing Russian
IA> roulette, with the philosophy that "what does not kill me makes me
IA> stronger." Try terminalia chebula instead. This is a lot safer.] |
| | IA> (reference #1)
IA> J Cell Biochem. 2004 Oct 15;93(3):588-97.
IA> Slow-down of age-dependent telomere shortening is executed in human skin
IA> keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by
IA> anti-oxidative effects of pro-vitamin C in common concurrently with
IA> reduction of intracellular oxidative stress.
IA> The cellular life-span of cultivated human skin epidermis
IA> keratinocytes NHEK-F was shown to be extended up to 150% of population
IA> doubling levels (PDLs) by repetitive addition with two
IA> autooxidation-resistant derivatives of ascorbic acid (Asc),
IA> Asc-2-O-phosphate (Asc2P), and
IA> Asc-2-O-alpha-glucoside (Asc2G),
IA> respectively, but to be not extended with Asc itself. In contrast,
IA> hydrogen peroxide (H(2)O(2)) as dilute as 20 microM which was
IA> non-cytotoxic to the keratinocytes, or at 60 microM being marginally
IA> cytotoxic achieved the cellular longevity, unexpectedly, up to 160
IA> and 120% of PDLs, respectively, being regarded as a hormesis-like
IA> stimulatory effect. The lifespan -extended cells that were administered
IA> with Asc2P, Asc2G, or 20 microM H(2)O(2) were prevented from
IA> senescence-induced symptoms such as PDL-dependent enlargement of a cell
IA> size of 14.7 microm finally up to 17.4 microm
IA> upon Hayflick's limit-called
IA> loss of proliferation ability as estimated with a channelizer, and
IA> retained young cell morphological aspects such as thick and compact
IA> shape and intense attachment to the culture
IA> substratum even upon advanced
IA> PDLs, whereas other non-extended cells looked
IA> like thin or fibrous shape
IA> and large size upon lower PDLs. The PDL-dependent shortening of telomeric
IA> DNA of 11.5 kb finally down to 9.12-8.10 kb upon Hayflick's limit was
IA> observed in common for each additive-given cells, but was decelerated in
IA> the following order: 20 microM H(2)O(2) > Asc2P = Asc2G > 60 microM |
H(2)O(2) >> Asc = no additive, being in
H(2)O(2) >> accord with the order of cell
| | IA> longevity. Intracellular reactive oxygen species (ROS) was diminished by
IA> Asc2P, Asc2G or 20 microM H(2)O(2), but not
IA> significantly by Asc or 60
IA> microM H(2)O(2) as estimated by fluorometry using the redox indicator dye
IA> CDCFH. There was no appreciable difference among NHEK keratinocytes that
IA> were administered with or without diverse additives in terms of
IA> telomerase activity per cell, which was 1.40 x 10(4)-4.48 x 10(4) times
IA> lower for the keratinocytes than for HeLa cells which were examined as
IA> the typical tumor cells. Thus longevity of the
IA> keratinocytes was suggested
IA> to be achieved by slowdown of age-dependent
IA> shortening of telomeric DNA
IA> rather than by telomerase; telomeres may suffer
IA> from less DNA lesions due
IA> to the continuous and thorough repression of
IA> intracellular ROS, which was
IA> realized either by pro-vitamin C such as Asc2P or Asc2G that exerted an
IA> antioxidant ability more persistent than Asc itself or by 20 microM
IA> H(2)O(2) which diminished intracellular ROS assumedly through a
IA> hormesis-like effect. |
| | IA> (reference #2)
IA> Exp Gerontol. 1988;23(3):211-6.
IA> Effect of hydrogen peroxide administration on life span, superoxide
IA> dismutase, catalase, and glutathione in the adult housefly, Musca
IA> domestica.
IA> The general objective of this study was to further elucidate the
IA> relationship between oxidative stress and the aging process. H2O2 is
IA> known to be a progenator of reactive oxygen
IA> species, such as hydroxyl
IA> free radical, by various mechanisms involving,
IA> among others, a superoxide
IA> anion radical-driven Fenton cycle, or splitting of the 0-0 bond by
IA> hemoproteins. Effects of H2O2 administration on life span, activities of
IA> superoxide dismutase, catalase, concentrations of endogenous H2O2, and
IA> glutathione in the housefly are described. Adult male flies were given
IA> various concentrations of H2O2, ranging from 0 to 100 mM H2O2, in their
IA> drinking water. Life span was shortened by H2O2 intake except in 10 mM
IA> H2O2 administrated flies, which exhibited the longest life span. Flies
IA> administered 10 mM H2O2 also contained the highest concentration of
IA> reduced glutathione (GSH). Superoxide dismutase and catalase activities
IA> were not affected by H2O2 intake. Compensatory elevation in GSH may be
IA> responsible for the increase in life span observed in 10 mM H2O2
IA> administered flies.
IA> <<< |
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