Fw: Life Extension Update May 14, 2013
Life Extension Update
High homocysteine, low folate and B12 predict macular degeneration
Tuesday, May 14, 2013. An article published ahead of print on May 1, 2013 in
the American Journal of Clinical Nutrition reports the finding of Australian
researchers of a protective effect for higher serum levels of vitamin B12
and folate against the risk of developing age-related macular degeneration
(AMD) in men and women aged 55 and older. The study also revealed a greater
risk of AMD in association with higher serum levels of homocysteine, which
is a risk factor for heart disease and peripheral vascular disease.
Paul Mitchell of the University of Sydney and his colleagues analyzed data
from 1,390 participants in the Blue Mountains Eye Study of common eye
diseases in residents aged 49 and older of a suburban Australian area. Eye
examinations were conducted upon enrollment and at five, ten and fifteen
years. Serum homocysteine, folate and vitamin B12 levels were measured and
food frequency questionnaires were completed at the five year follow-up
visit.
Carnosic acid protects the eyes
The November, 2012 issue of the journal Investigative Ophthalmology & Visual
Science reported that carnosic acid, a compound occurring in the herb
rosemary, helped protect the eyes' retina from degeneration and hydrogen
peroxide-induced toxicity.
Acting on previous findings of a protective effect for carnosic acid against
free-radical damage in the brain, Stuart A. Lipton, MD, PhD, who is the
director of Sanford-Burnham Medical Research Institute's Del E. Webb
Neuroscience, Aging, and Stem Cell Research Center, and his colleagues
tested the effect of carnosic acid on retina-derived cell lines treated with
hydrogen peroxide, which promotes oxidative stress, a factor believed to be
involved in the progression of age-related macular degeneration and
retinitis pigmentosa. The team found that carnosic acid induced the
production of antioxidant enzymes and lowered free radicals and peroxides.
In a study involving dark-adapted rats, those that received carnosic acid
prior to white light exposure experienced less retinal damage. Increases in
outer retinal nuclear layer thickness measured in carnosic acid-treated
animals indicated improved retinal photoreceptor protection. Treated rats
also exhibited improved electroretinogram activity, a measure of
photoreceptor function. "These findings suggest that carnosic acid may
potentially have clinical application to diseases affecting the outer
retina, including age-related macular degeneration and retinitis pigmentosa,
in which oxidative stress is thought to contribute to disease progression,"
the authors conclude.
Dr Lipton revealed that "We're now developing improved derivatives of
carnosic acid and related compounds to protect the retina and other brain
areas from a number of degenerative conditions, including age-related
macular degeneration and various forms of dementia." Life Extension
Magazine(R) May, 2013 Issue Now Online!
On the cover:
Why some people live so long! Identifying what enables humans to survive
past 110 in good health, by James Clement
Reports:
Boost immune function ... while suppressing overactive immune attacks, by
Michael Downey
A better form of vitamin C, by Steven Cortez
Better brain chemistry with tryptophan, by Travis Harding
The 2012 A4M Symposium in Dubai, UAE, by Ben Best
Departments:
As we see it: Federal death panels, by William Faloon
In the news: Macular degeneration, diabetes, mood and more, by D. Dye and M.
Richmond
Wellness Profile: David Justice Ross living life to the fullest, by Jon
Finkel
Book Review: The Blood Sugar Solution, by Mark Hyman, MD
Journal abstracts:
Tryptophan, vitamin C, Tinofend
Всем привет.
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С уважением,
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