А кто сказал, что это доксициклин, прошелся по ссылкам - неубедительно.
PubMed дает совсем другой результат, вот, например, последняя статья.
Cell Death Dis. <http://www.ncbi.nlm.nih.gov/pubmed/23703389>2013 May
23;4:e644. doi: 10.1038/cddis.2013.169.
NLRP3 activation induces ASC-dependent programmed necrotic cell death,
which leads to neutrophilic inflammation.
Satoh T
<http://www.ncbi.nlm.nih.gov/pubmed?term=Satoh%20T%5BAuthor%5D&cauthor=true&cauthor_uid=23703389>,
Kambe N
<http://www.ncbi.nlm.nih.gov/pubmed?term=Kambe%20N%5BAuthor%5D&cauthor=true&cauthor_uid=23703389>,
Matsue H
<http://www.ncbi.nlm.nih.gov/pubmed?term=Matsue%20H%5BAuthor%5D&cauthor=true&cauthor_uid=23703389>.
Source
Department of Dermatology, Chiba University Graduate School of Medicine,
Chiba, Japan.
Abstract
NLR family pyrin domain containing 3 (NLRP3) is a cytoplasmic pattern
recognition receptor that regulates innate immune responses by forming a
protein complex, the inflammasome. It leads to production of
proinflammatory cytokine productions such as interleukin 1?(IL-1?). We
and others demonstrated that an induction of activated NLRP3 also
induced cell death. However, little is known about the characteristics
and mechanisms of the cell death and its involvement in the pathogenesis
of inflammatory conditions. In this study, we established cell lines in
which NLRP3 was induced by doxycycline using a tetracycline-inducible
expression (Tet-on) system. Using this system, the expression of NLRP3
mutants in cryopyrin-associated periodic syndrome (CAPS) patients was
sufficient for the induction of necrotic cell death without
lipopolysaccharide stimulation or generation of mature IL-1?. We also
found that CA074-Me, a cathepsin B inhibitor, blocked cell death before
oligomerization of apoptosis-associated speck-like protein containing a
CARD (ASC), whereas Z-VAD-fmk, a pan-caspase inhibitor, blocked the cell
death after the oligomerization. Silencing of the ASC gene (Pycard) by
small hairpin RNA treatment inhibited the NLRP3 mutant-induced cell
death, but silencing of the caspase-1 gene (Casp1) did not. Taken
together, these results indicated that ASC was indispensable for
NLRP3-mediated programmed necrotic cell death, and that this type of
cell death was distinct from 'pyroptosis', which requires caspase-1.
Finally, we demonstrated in an in vivo model that the programmed
necrotic cell death induced by activated NLRP3 could cause neutrophil
infiltration, indicating a possible role of cell death in neutrophil
infiltration of skin lesions in CAPS patients.
http://www.ncbi.nlm.nih.gov/pubmed/23703389
> http://www.eternalmind.ru/index.php?option=com_content&task=view&id=4806&Itemid=1
>
>
> 25 мая 2013 г., 23:20 пользователь S <kon***@a*****.ru> написал:
>
>> Здравствуйте, Igor.
>> Good morning, afternoon, evening, Igor.
>> Saturday, May 25, 2013
>> Вы писали 25 мая 2013 г., 22:35:22:
>> You wrote 25.05.2013, 22:35:22:
>>
>> I> 24 мая 2013 г., 17:23 пользователь S <kon***@a*****.ru> написал:
>>
>>>> Интересно, какие антибиотики имеют в виду?
>>
>> I> Доксициклин.
>>
>> Ннда, даже не подумал бы... Куча побочных эффектов.
>>
>>
>> --
>> Планы на будущее, не совпадающие с вашими умственными, физическими или
>> финансовыми
>> возможностями называются мечтами.
>>
>> С уважением, Кондратьев Сергей.
>> Sincerely yours, Kondratiev S.V.
>> Saturday, May 25, 2013 mailto:kon***@a*****.ru
>>
>> --
>> Дискуссионный лист сайта Bessmertie.Ru
>>
>>
>>
