инсулин; магний-глюкоза
http://www.lef.org/newsletter/2013/0129_Meta-Analysis-Links-Increased-Magnesium-Intake-With-Fasting-Glucose-And-Insulin-Reductions.htm
Meta-analysis links increased magnesium intake with fasting glucose and
insulin reductions
Tuesday, January 29, 2013. The results of a meta-analysis published online
on January 23, 2013 in the Journal of Nutrition reveal an association
between diets that include higher amounts of magnesium and lower levels of
fasting glucose and insulin.
American and European researchers sought to determine the influence of
genetic variations associated with glycemic traits or magnesium metabolism
on fasting glucose and insulin levels, which are elevated in metabolic
syndrome and type 2 diabetes. "Evidence from cross-sectional and
longitudinal observational studies suggests that diets higher in magnesium
are associated with reduced risk of insulin resistance and type 2 diabetes,
whereas in intervention studies, supplemental magnesium improves measures of
glucose and insulin metabolism in generally healthy adults, as well as in
those with insulin resistance and type 2 diabetes," Adela Hruby and
colleagues write. "However, little is known about potential interaction
between magnesium intake and genetic variability on glycemic traits, in
which genetic variants related to either magnesium transport and homeostasis
or glucose and insulin metabolism may modify the pathways through which
magnesium exerts its effects."
The researchers analyzed data from up to 52,684 nondiabetic men and women
who participated in 15 studies included in the Cohorts for Heart and Aging
Research in Genomic Epidemiology (CHARGE) Consortium. Dietary questionnaire
or interview responses, or food diary entries were analyzed for magnesium
content from food and beverages. Participants were genotyped for up to 25
single nucleotide polymorphisms related to fasting glucose, insulin or
magnesium.
Average magnesium intake ranged from 224.7 milligrams to 479.7 milligrams
per day. Reductions in both fasting glucose and fasting insulin were
observed in association with increased magnesium. While a nominal
association was found between one of the genetic variants examined in this
study and fasting glucose and two variants showed nominal interactions with
magnesium intake on fasting glucose and fasting insulin, no significant
effects for the variations were observed.
"To our knowledge, this is one of the largest observational studies to
investigate magnesium intake's associations with fasting glucose and fasting
insulin, and it is the largest meta-analysis investigating interactions
between magnesium intake and risk loci on fasting glucose and fasting
insulin," the authors announce.
"Our results indicate that higher dietary magnesium intake is inversely
associated with fasting glucose and fasting insulin in individuals free of
diabetes, generally irrespective of genetic variation at glycemia- and
magnesium-related loci investigated," they conclude.
