Review finds improved survival in clinical trials of vitamin D3 supplementation - Life Extension Update
длительный обзор, опубликованный 5 июля 2011 года в библиотеке Cochrane
показывает, что употребление пожилыми людьми витамина D3 связано со
снижением смертности за два года средний срок.
http://www.lef.org/newsletter/2011/0708_Improved-Survival-Clinical-Trials-Vitamin-D3-Supplementation.htm?source=eNewsLetter2011Wk27-2&key=Article&l=0#article
A lengthy review published on July 5, 2011 in The Cochrane Library reveals
that supplementing older individuals with vitamin D3 is associated with
reduced mortality over a two year average period.
Goran Bjelakovic of the University of Nis in Serbia and his European
associates selected 50 randomized trials involving vitamin D
supplementation, which provided a total of 94,148 participants for their
analysis. Most of the trials analyzed the effect of supplementation on bone
mineral density, falls and fractures. The subjects' average age was 74, and
79 percent were female. The median length of supplementation with vitamin D
was two years.
Dr Bjelakovic and his colleagues uncovered a significant benefit for
supplementation with vitamin D3, but not for other forms of the vitamin, on
improving survival over the course of the trials. "A Cochrane meta-analysis
published only a couple of years ago found that there was some evidence for
benefit, but it could not find an effect on mortality," commented Dr
Bjelakovic, who is affiliated with the University of Nis' Department of
Internal Medicine - Gastroenterology and Hepatology. "We were, however,
aware that more trials had been published and wanted to assess the effects
of vitamin D when you added all the data together."
"Our analyses suggest that vitamin D3 reduces mortality by about 6%," he
concluded. "This means that you need to give about 200 people vitamin D3 for
around two years to save one additional life."
Because there were fewer trials involving other forms of the vitamin
included in the current analysis, the apparent absence of a survival benefit
for these forms needs to be taken with caution. "We need to have more
randomized trials that look specifically to see whether these forms of
vitamin D do or don't have benefits," Dr Bjelakovic stated.
"Previous reviews of preventive trials of vitamin D have not included as
much information and have not examined the separate influence of different
forms of vitamin D on mortality," he added. "By taking data from a larger
number of trials we have been able to shed much more light on this important
issue."
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